The most prominent of their children was the Rev. James Pierpont, who seceded the Rev. Davenport in the pastorate of the Church in New Haven, and was largely instrumental in the founding of Yale College.
He was married three times; his first wife died only about four months after her marriage, his second wife had one child and died soon after. His third wife was Mary Hooker, granddaughter of Rev. Thomas Hooker, by whom he had a daughter who became the wife of the noted Devine Rev. Jonathan Edwards.